Put a set on the wife's E350 about 4K miles ago, and I am very impressed with the tire. Ride, wet handling, road noise, all are very good. Not quite to the level that the Pilot S/S on my Z4! But for an all season tire, I would recommend. Now rear tire life on an E350? We'll see.
The DSW that were on the car when we bought it got about 18K out of the rears, and the first set of A/S that we put on got about 24K on the rears (gotta get her to quit the burn outs!); so we shall see what the A/S 3's do.