It's my belief that over 90% of the bearing wear occurs between 7500-8000RPM.
A tune/setup has power peaking at >7500 may be your best compromise between power/wear.
I got lucky with my setup in that the power peaks at around 7200 and when driving hard I shift as the tach just touches the yellow.
My lead never comes back over 1-2PPM on UOA and most often is 0.
Toy: 2008 Silver Z4MC 300WHP/241TQ
Mods: OEM Euro Headers, RPI Scoop
Daily: 2010 Tacoma Double Cab